Cyanogen bromide fragments of apoC-II corresponding to residues 1-9 and 10-59 had little ability to activate LPL. To determine the minimal sequence requirements for activation, we have prepared both native and synthetic fragments of apoC-II and tested them for their ability to activate LPL. ![]() The amino acid sequence of the 78 residues of apoC-II has recently been established in this laboratory. Apolipoprotein C-II (apoC-II), a protein constituent of human very low density lipoproteins, is the activator for lipoprotein lipase (LPL triacylglycerol acyl-hydrolase, EC 3.1.1.3).
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